This article is an excellent introduction to the unique challenges of severe or very severe ME/CFS. It covers the symptoms and pathology, the specialised care that is required from healthcare providers, common misunderstandings around severe M.E. (i.e., that it is psychological or the result of neglect), diagnosis and assessment, treatment and management, and the best way to collaborate with caregivers. This is a very informative read for health professionals, caregivers, and anyone wishing to learn more about severe ME/CFS.
Full article can be found here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544443/