In a recent News & Views article published in the journal Nature Cardiovascular Research, researchers report the frequencies of novel postural orthostatic tachycardia syndrome (POTS)-related diagnoses including POTS, fatigue, dysautonomia, Ehlers–Danlos syndrome, and mast cell diseases, prior to and after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination.
Overall, the study findings showed that new-onset POTS diagnoses and POTS-related diagnoses occurred more frequently following COVID-19 vaccination as compared to the pre-vaccination period.
Nevertheless, the rate of new POTS diagnoses was more than five-fold greater post-COVID-19 as compared to that following vaccinations.