Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomised, Double-Blind, Placebo-Controlled Trial
Study Design and Task Details:
This randomised, double-blind, placebo-controlled trial aimed to evaluate the effects of Coenzyme Q10 (CoQ10) combined with Nicotinamide Adenine Dinucleotide (NADH) supplementation on fatigue perception and health-related quality of life (HRQoL) in individuals diagnosed with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A total of 207 participants were enrolled and randomly assigned to receive either the CoQ10 plus NADH supplement or a placebo over an eight-week period. Assessments were conducted at baseline, four weeks, and eight weeks, utilising validated instruments such as the Fatigue Impact Scale (FIS-40), the Pittsburgh Sleep Quality Index (PSQI), and the Short Form Health Survey (SF-36) to measure fatigue levels, sleep quality, and HRQoL, respectively.
Key Findings:
· Participants receiving CoQ10 plus NADH supplementation exhibited significant improvements in physical functioning scores at both the four-week (p = 0.036) and eight-week (p = 0.001) assessments compared to baseline.
· The bodily pain domain showed significant improvement at the four-week mark (p = 0.043).
· Improvements were also noted in cognitive fatigue and sleep quality among the supplemented group.
· No significant differences were observed between the supplemented and placebo groups in intergroup analyses.
The supplementation was well-tolerated, with no relevant treatment-related adverse events reported.
Conclusion:
The study suggests that an eight-week regimen of CoQ10 plus NADH supplementation may lead to improvements in physical functioning, reduction in bodily pain, and enhancements in cognitive fatigue and sleep quality among individuals with ME/CFS. While intragroup improvements were significant, the lack of significant intergroup differences indicates the need for further research to confirm these findings and to explore the potential benefits of CoQ10 and NADH supplementation in this patient population.
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Reference
Castro-Marrero, J., Segundo, M. J., Lacasa, M., Martinez-Martinez, A., Sentañes, R. S., & Alegre-Martin, J. (2021). Effect of dietary coenzyme Q10 plus NADH supplementation on fatigue perception and health-related quality of life in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: a prospective, randomized, double-blind, placebo-controlled trial. Nutrients, 13(8), 2658.